Mitchell R McGill Selected Research

Acetaminophen (Paracetamol)

1/2022	Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways.
1/2022	Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.
9/2019	Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.
6/2019	Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
1/2019	Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.
1/2019	Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats.
1/2018	Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms.
1/2018	Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis.
10/2017	Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity.
1/2017	Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice.

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Mitchell R McGill Research Topics

Disease

20	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022 - 03/2011
19	Mitochondrial Diseases (Mitochondrial Disease) 10/2017 - 03/2011
15	Chemical and Drug Induced Liver Injury 12/2021 - 02/2012
15	Necrosis 01/2019 - 01/2012
5	Inflammation (Inflammations) 01/2021 - 07/2014
4	Liver Diseases (Liver Disease) 10/2020 - 12/2015
3	Non-alcoholic Fatty Liver Disease 01/2021 - 09/2012
3	Hepatitis 01/2017 - 08/2014
2	Ischemia 01/2021 - 06/2013
2	Cholestasis 01/2020 - 12/2014
2	Body Weight (Weight, Body) 04/2019 - 01/2016
2	Ototoxicity 01/2019 - 02/2016
2	Obesity 02/2016 - 09/2012
2	Poisoning 12/2015 - 01/2015
2	Hepatocellular Carcinoma (Hepatoma) 09/2015 - 01/2015
2	Liver Failure 07/2015 - 12/2012
2	Drug-Related Side Effects and Adverse Reactions 09/2014 - 02/2012
1	Fibrosis (Cirrhosis) 01/2022
1	Reperfusion Injury 01/2021
1	Insulin Resistance 01/2021
1	Weight Loss (Weight Reduction) 10/2020
1	Respiratory Hypersensitivity 09/2019
1	Asthma (Bronchial Asthma) 09/2019
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 06/2019
1	Hepatitis C 01/2019
1	Confusion (Bewilderment) 01/2018
1	Pain (Aches) 01/2018
1	Fever (Fevers) 01/2018
1	Acute Kidney Injury (Acute Renal Failure) 01/2018
1	Hearing Loss (Hearing Impairment) 02/2016
1	Thrombocytopenia (Thrombopenia) 10/2015
1	End Stage Liver Disease 10/2014

Drug/Important Bio-Agent (IBA)

43	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2022 - 03/2011
14	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2013
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2011
8	Pharmaceutical PreparationsIBA 01/2019 - 12/2012
8	Oxidants (Oxidizing Agents)IBA 12/2015 - 03/2011
5	Alanine Transaminase (SGPT)IBA 01/2022 - 12/2012
4	EnzymesIBA 01/2021 - 12/2015
3	Glutathione (Reduced Glutathione)IBA 01/2019 - 03/2011
3	JNK Mitogen-Activated Protein KinasesIBA 03/2016 - 01/2013
2	Keratin-18 (Keratin 18)IBA 01/2022 - 01/2012
2	Glutamate DehydrogenaseIBA 01/2022 - 07/2013
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2022 - 03/2011
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 02/2016
2	Methamphetamine (Desoxyn)FDA LinkGeneric 10/2020 - 01/2019
2	BilirubinIBA 04/2019 - 01/2016
2	Mitochondrial DNA (mtDNA)IBA 10/2017 - 10/2014
2	Transaminases (Aminotransferases)IBA 05/2017 - 09/2012
2	EndonucleasesIBA 01/2017 - 07/2015
2	Protein Kinases (Protein Kinase)IBA 10/2016 - 12/2013
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 03/2016 - 12/2015
2	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 02/2016 - 09/2012
2	Furosemide (Lasix)FDA LinkGeneric 02/2016 - 02/2014
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2015 - 06/2015
2	Adenosine Triphosphate (ATP)IBA 09/2015 - 01/2015
2	MicroRNAs (MicroRNA)IBA 08/2014 - 07/2014
1	K-18 conjugate (K18)IBA 01/2022
1	Antisense OligonucleotidesIBA 01/2021
1	2-acylglycerol O-acyltransferaseIBA 01/2021
1	MonoglyceridesIBA 01/2021
1	DiglyceridesIBA 01/2021
1	CannabidiolIBA 06/2019
1	Nonprescription Drugs (Patent Medicines)IBA 06/2019
1	AminoglycosidesIBA 01/2019
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2019
1	Opioid Analgesics (Opioids)IBA 01/2019
1	Oxygen (Dioxygen)IBA 01/2017
1	CytokinesIBA 01/2017
1	CaspasesIBA 10/2016
1	GalactosamineIBA 10/2016
1	Dactinomycin (Actinomycin)FDA LinkGeneric 10/2016
1	LipopolysaccharidesIBA 10/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2016
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 10/2016
1	quinone (benzoquinone)IBA 03/2016
1	IminesIBA 03/2016
1	XenobioticsIBA 02/2016
1	Kanamycin FDA Link 02/2016
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/2016
1	Small Interfering RNA (siRNA)IBA 01/2016
1	ConnexinsIBA 01/2016
1	torinIBA 01/2016
1	leupeptinIBA 01/2016
1	Chloroquine (Aralen)FDA LinkGeneric 01/2016
1	Biological ProductsIBA 12/2015
1	ResveratrolIBA 12/2015
1	Benzyl Alcohol (Benzenemethanol)FDA Link 12/2015
1	AntidotesIBA 12/2015
1	3-hydroxyacetanilideIBA 12/2015
1	Bile Acids and Salts (Bile Acids)IBA 12/2014
1	Glycodeoxycholic AcidIBA 12/2014
1	Circulating MicroRNAIBA 08/2014
1	Acetylcysteine (Siran)FDA LinkGeneric 02/2014
1	Apoptosis Inducing FactorIBA 12/2013
1	fas Receptor (CD95 Antigen)IBA 08/2013
1	Cysteine (L-Cysteine)FDA Link 06/2013

Therapy/Procedure

3	Ligation 10/2020 - 01/2019
1	Liver Transplantation 01/2021
1	Drug Therapy (Chemotherapy) 10/2020